Sepe is an Italian surname. Notable people with the surname include:
- Angelo Sepe, (1941–1984) Italian-American gangster
- Crescenzio Sepe, Italian cardinal
- Daniele Sepe, Italian musician
- Frank Sepe, American fitness author
- Luigi Sepe, Italian footballer
- Majda Sepe, (1937–2006) Slovenian singer
- Michele Sepe, Italian rugby player
- Mimmo Sepe (died 2020), Italian comedian
Surname listThis page lists people with the surname Sepe. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. Categories: