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Medical sign involving partial eyebrow loss
Medical condition
Sign of Hertoghe
Other names
Queen Anne's sign
Anne of Denmark mourning the death of her son Henry in 1612
The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a classical sign of hypothyroidism or atopic dermatitis, but it can also be detected in lepromatous leprosy. The sign is named after the Belgian internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research.
