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Small Cajal body specific RNA 8

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Small Cajal body specific RNA 8
Predicted secondary structure and sequence conservation of SCARNA8
Identifiers
SymbolSCARNA8
Alt. SymbolsU92
RfamRF00286
Other data
RNA typeGene; snRNA; snoRNA; scaRNA
Domain(s)Eukaryota
GOGO:0006396 GO:0015030 GO:0005730
SOSO:0000275
PDB structuresPDBe

Small Cajal body specific RNA 8 (also known as SCARNA8 or U92) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U2 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

U92 belong to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1. It is predicted to guide the pseudouridylation of residues U44 in U2 snRNA. This snoRNA is related to the mouse H/ACA box snoRNA MBI-57.

References

  1. ^ Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
  2. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.

External links

Small Cajal body-specific RNA
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