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Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated. In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability. Nowadays, stRNAs are better known as miRNAs.

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their roles in RNA interference (RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms.

References

1. Ambros V (August 2001). "Development. Dicing up RNAs". Science. 293 (5531): 811–3. doi:10.1126/science.1064400. PMID 11486075. S2CID 45706655.
2. Grosshans H, Slack FJ (January 2002). "Micro-RNAs: small is plentiful". The Journal of Cell Biology. 156 (1): 17–21. doi:10.1083/jcb.200111033. PMC 2173595. PMID 11781331.
3. Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". BioEssays. 24 (2): 119–29. doi:10.1002/bies.10046. PMID 11835276.

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