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Southern Comfort is a brand of liqueur.

Southern Comfort may also refer to:

Music

• Matthews Southern Comfort, a band headed by Iain Matthews formed in 1969
• "Southern Comfort", a 1990 song by Suzi Quatro from Oh, Suzi Q.

Albums

• Southern Comfort (Anthony Hamilton album), 2007
• Southern Comfort (Conway Twitty album) or the title song, 1982
• Southern Comfort (The Crusaders album) or the title song, 1974
• Southern Comfort (Frank Wess album) or the title song, 1962
• Southern Comfort, by Psychic TV
• The Southern Comfort, by Emil Bulls, or the title song, 2005

Other uses

• Southern Comfort Conference, an annual conference for people affected by transgender issues, formed in 1991
• Southern Comfort (1981 film), an American film by Walter Hill
• Southern Comfort (2001 film), a documentary film that takes its name from the annual conference

• Disambiguation pages