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Walker O. Cain, of the firm Steinman, Cain & White – successor firm to McKim, Mead and White – with Édouard Utudjian of Paris as a consultant, designed the cathedral. The building includes two unique features distinct to Armenian architecture: the use of double-intersecting arches and a pyramidal dome soaring 120 feet (37 m) above street level.
Around the dome there are various symbols, including the figure of Jesus Christ; the Holy Spirit represented by a dove; the Greek lettersalpha and omega superimposed on the scriptures; wheat and grapes representing the Eucharist; and the Phoenix symbolizing resurrection etc. A series of high, narrow, stained-glass windows are set into the main walls of the cathedral below the dome depicting scenes in the life of Christ and early Christianity in Armenia. The patron saint of the cathedral, St. Vartan, is depicted fighting the Sassanid Persians who threatened the Armenian Church during the fifth century. Ecumenism is symbolized in the portrait of St. Nerses and the crosses of Christendom.
A raised plaza is located on the south side of the cathedral, which contains a 10-foot (3.0 m) high Reuben Nakian bronze sculpture, "Descent from the Cross" that was dedicated in 1977 and inspired by the painting The Raising of the Cross as well as a stainless steel and bronze sculpture, "Migrations" by Michael Aram that was added in 2015 to commemorate the centennial of the Armenian genocide.
^ "The Artistry of St. Vartan Cathedral". History of St. Vartan Cathedral. The Diocese of the Armenian Church of America (Eastern). Retrieved January 6, 2008.
"1960s". History of St. Vartan Cathedral. The Diocese of the Armenian Church of America (Eastern). Retrieved January 6, 2008.