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TBL1X
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XTC, 2XTD, 2XTE
Identifiers
Aliases	TBL1X, EBI, SMAP55, TBL1, transducin (beta)-like 1X-linked, transducin beta like 1X-linked, transducin beta like 1 X-linked, CHNG8
External IDs	OMIM: 300196; MGI: 1336172; HomoloGene: 4128; GeneCards: TBL1X; OMA:TBL1X - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.31-p22.2 Start 9,463,320 bp End 9,741,037 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A7.3- B|X 38.31 cM Start 76,554,619 bp End 76,706,589 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis seminal vesicula corpus epididymis renal medulla caput epididymis buccal mucosa cell optic nerve dorsal motor nucleus of vagus nerve inferior olivary nucleus secondary oocyte Top expressed in tail of embryo genital tubercle ascending aorta maxillary prominence mandibular prominence atrium aortic valve efferent ductule left lung lobe calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding transcription corepressor activity protein domain specific binding histone binding transcription factor binding protein C-terminus binding protein binding identical protein binding Cellular component histone deacetylase complex transcription repressor complex nucleoplasm spindle microtubule nucleus mitotic spindle Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II hearing transcription, DNA-templated proteolysis positive regulation of transcription, DNA-templated histone deacetylation positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process regulation of lipid metabolic process positive regulation of canonical Wnt signaling pathway protein stabilization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6907 21372 Ensembl ENSG00000101849 ENSMUSG00000025246 UniProt O60907 Q9QXE7 RefSeq (mRNA) NM_001139466 NM_001139467 NM_001139468 NM_005647 NM_020601 RefSeq (protein) NP_001132938 NP_001132939 NP_001132940 NP_005638 NP_065626 Location (UCSC) Chr X: 9.46 – 9.74 Mb Chr X: 76.55 – 76.71 Mb PubMed search
Wikidata
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Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.

Function

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.

Interactions

TBL1X has been shown to interact with:

• GPS2, and
• HDAC3,
• NCOA1, and
• NCOA2.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000101849 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025246 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: TBL1X transducin (beta)-like 1X-linked".
6. ^ Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
7. ^ Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID 10809664.
8. ^ Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
9. ^ Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
10. Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (December 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.

Further reading

• Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G (1999). "X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats". Am. J. Hum. Genet. 64 (6): 1604–16. doi:10.1086/302408. PMC 1377903. PMID 10330347.
• Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID 10809664.
• Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
• Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
• Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
• Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
• Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG (2004). "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors". Cell. 116 (4): 511–26. doi:10.1016/S0092-8674(04)00133-3. PMID 14980219. S2CID 18807923.
• Yoon HG, Choi Y, Cole PA, Wong J (2005). "Reading and function of a histone code involved in targeting corepressor complexes for repression". Mol. Cell. Biol. 25 (1): 324–35. doi:10.1128/MCB.25.1.324-335.2005. PMC 538779. PMID 15601853.
• Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O (2005). "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization". Cell Cycle. 4 (11): 1632–40. doi:10.4161/cc.4.11.2151. PMID 16258276.

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