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TOB2
Identifiers
Aliases	TOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396; MGI: 1888525; HomoloGene: 9447; GeneCards: TOB2; OMA:TOB2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 41,433,494 bp End 41,446,801 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 81,732,473 bp End 81,742,997 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve paraflocculus of cerebellum gastric mucosa mucosa of paranasal sinus muscle of thigh popliteal artery tibial arteries gastrocnemius muscle right hemisphere of cerebellum Skeletal muscle tissue of rectus abdominis Top expressed in ascending aorta aortic valve retinal pigment epithelium ciliary body neural layer of retina brown adipose tissue epithelium of lens medial head of gastrocnemius muscle primary oocyte masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding vitamin D receptor binding transcription corepressor activity Cellular component nucleus cytoplasm cytosol Biological process positive regulation of ossification female gamete generation negative regulation of osteoclast differentiation regulation of gene expression negative regulation of cell population proliferation signaling negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10766 57259 Ensembl ENSG00000183864 ENSMUSG00000048546 UniProt Q14106 Q9JM55 RefSeq (mRNA) NM_016272 NM_020507 RefSeq (protein) NP_057356 NP_065253 Location (UCSC) Chr 22: 41.43 – 41.45 Mb Chr 15: 81.73 – 81.74 Mb PubMed search
Wikidata
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Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.

Interactions

TOB2 has been shown to interact with CNOT7.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000183864 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000048546 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
7. ^ "Entrez Gene: TOB2 transducer of ERBB2, 2".
8. "TOB2 transducer of ERBB2, 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-09-24.

Further reading

• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
• Suzuki T, Matsuda S, Tsuzuku JK, et al. (2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes Cells. 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
• Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". Eur. J. Biochem. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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