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tRNA pseudouridine synthase (EC 5.4.99.27, TruD, YgbO, tRNA PSI13 synthase, RNA:PSI-synthase Pus7p, Pus7p, RNA:pseudouridine-synthase Pus7p, Pus7 protein) is an enzyme with systematic name tRNA-uridine uracil mutase. This enzyme catalyses the following chemical reaction

tRNA uridine ${\displaystyle \rightleftharpoons }$ tRNA pseudouridine

Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine in tRNA.

References

1. Ericsson UB, Nordlund P, Hallberg BM (May 2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Letters. 565 (1–3): 59–64. doi:10.1016/j.febslet.2004.03.085. PMID 15135053. S2CID 31602560.
2. Chan CM, Huang RH (September 2009). "Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases". Archives of Biochemistry and Biophysics. 489 (1–2): 15–9. doi:10.1016/j.abb.2009.07.023. PMID 19664587.
3. Kaya Y, Ofengand J (June 2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA. 9 (6): 711–21. doi:10.1261/rna.5230603. PMC 1370438. PMID 12756329.
4. Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C (November 2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs". RNA. 9 (11): 1371–82. doi:10.1261/rna.5520403. PMC 1287059. PMID 14561887.
5. Urban A, Behm-Ansmant I, Branlant C, Motorin Y (February 2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p" (PDF). The Journal of Biological Chemistry. 284 (9): 5845–58. doi:10.1074/jbc.m807986200. PMID 19114708. S2CID 19586610.

External links

• TRNA+pseudouridine13+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 5.4.99