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TSEN15

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Protein-coding gene in the species Homo sapiens
TSEN15
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2GW6

Identifiers
AliasesTSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDsOMIM: 608756; MGI: 1913887; HomoloGene: 12002; GeneCards: TSEN15; OMA:TSEN15 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for TSEN15Genomic location for TSEN15
Band1q25.3Start184,051,651 bp
End184,123,978 bp
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)
Chromosome 1 (mouse)Genomic location for TSEN15Genomic location for TSEN15
Band1|1 G2Start152,246,486 bp
End152,262,439 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • C1 segment

  • biceps brachii

  • vastus lateralis muscle

  • Skeletal muscle tissue of biceps brachii

  • corpus epididymis

  • Brodmann area 46

  • deltoid muscle

  • ventricular zone
Top expressed in
  • yolk sac

  • epiblast

  • embryo

  • ventricular zone

  • embryo

  • quadriceps femoris muscle

  • olfactory bulb

  • placenta

  • heart

  • skeletal muscle tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116461

66637

Ensembl

ENSG00000198860

ENSMUSG00000014980

UniProt

Q8WW01

Q8R3W5

RefSeq (mRNA)

NM_001127394
NM_001300764
NM_001300766
NM_052965
NM_001363643

NM_025677

RefSeq (protein)

NP_001120866
NP_001287693
NP_001287695
NP_443197
NP_001350572

NP_079953

Location (UCSC)Chr 1: 184.05 – 184.12 MbChr 1: 152.25 – 152.26 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).

Interactions

C1orf19 has been shown to interact with TSEN2.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000198860 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000014980 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
  6. Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
  7. ^ "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
  8. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

Further reading

PDB gallery
  • 2gw6: NMR structure of the human tRNA endonuclease SEN15 subunit 2gw6: NMR structure of the human tRNA endonuclease SEN15 subunit


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