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Taxoid 7beta-hydroxylase

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Class of enzymes
Taxoid 7beta-hydroxylase
Identifiers
EC no.1.14.13.147
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Taxoid 7beta-hydroxylase (EC 1.14.13.147) is an enzyme with systematic name taxusin,NADPH:oxygen 7-oxidoreductase. This enzyme catalyses the following chemical reaction

taxusin + O2 + NADPH + H {\displaystyle \rightleftharpoons } 7beta-hydroxytaxusin + NADP + H2O

Taxoid 7beta-hydroxylase requires cytochrome P450.

References

  1. Chau M, Jennewein S, Walker K, Croteau R (May 2004). "Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase". Chemistry & Biology. 11 (5): 663–72. doi:10.1016/j.chembiol.2004.02.025. PMID 15157877.

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Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate
1.14.13: NADH or NADPH
1.14.14: reduced flavin or flavoprotein
1.14.15: reduced iron–sulfur protein
1.14.16: reduced pteridine (BH4 dependent)
1.14.17: reduced ascorbate
1.14.18-19: other
1.14.99 - miscellaneous
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