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TEKT1
Identifiers
Aliases	TEKT1, tektin 1
External IDs	OMIM: 609002; MGI: 1333819; HomoloGene: 7973; GeneCards: TEKT1; OMA:TEKT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 6,789,133 bp End 6,831,761 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B4 Start 72,235,548 bp End 72,253,268 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa mucosa of paranasal sinus left testis right testis sperm epithelium of nasopharynx testicle nasal epithelium Top expressed in spermatid seminiferous tubule spermatocyte utricle olfactory epithelium morula vestibular sensory epithelium Epithelium of choroid plexus right lung lobe choroid plexus of fourth ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule cytoskeleton cell projection cilium microtubule cytoskeleton nucleus sperm flagellum motile cilium Biological process flagellated sperm motility cilium assembly cilium movement involved in cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83659 21689 Ensembl ENSG00000167858 ENSMUSG00000020799 UniProt Q969V4 Q9DAJ2 RefSeq (mRNA) NM_053285 NM_001282006 NM_001282007 NM_011569 RefSeq (protein) NP_444515 NP_001268935 NP_001268936 NP_035699 Location (UCSC) Chr 17: 6.79 – 6.83 Mb Chr 11: 72.24 – 72.25 Mb PubMed search
Wikidata
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Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.

Function

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000167858 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020799 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: tektin 1".
6. Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Newby PR, Pickles OJ, Mazumdar S, et al. (2010). "Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study". Eur. J. Hum. Genet. 18 (9): 1021–6. doi:10.1038/ejhg.2010.55. PMC 2987410. PMID 20442750.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Iguchi N, Tanaka H, Nakamura Y, et al. (2002). "Cloning and characterization of the human tektin-t gene". Mol. Hum. Reprod. 8 (6): 525–30. doi:10.1093/molehr/8.6.525. PMID 12029069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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