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Tetrafylia (Greek: Τετραφυλία) is a former municipality in the Arta regional unit, Epirus, Greece. Since the 2011 local government reform it is part of the municipality Georgios Karaiskakis, of which it is a municipal unit. The municipal unit has an area of 159.823 km. Population 2,248 (2021). The seat of the municipality was in Astrochori.