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Thug Disease is a compilation presented by American rapper Spice 1. It was released December 17, 2002 on Rap Classics, and also separately on Lovin' Paper Music Group. The album features guest performances by Kurupt, Bad Azz, Juvenile, MJG, Roscoe, Brotha Lynch Hung and UGK.
Two tracks, "Muder Man Dance" and "Chocolate Philly", were previously released on the Spice 1 album, The Last Dance. One song, "Ballin", was previously released on the Lil' Keke album, Birds Fly South.