Tlaxcala is a Mexican state.
Tlaxcala may also refer to:
- Tlaxcala (city), the capital city of the Mexican state of Tlaxcala and seat of the municipality
- Tlaxcala Territory 1824–1857
- Tlaxcala (Nahua state), the pre-Columbian city and state
See also
- Tlaxcaltec, a Nahua people who live in the Mexican state of Tlaxcala
- San Esteban de Nueva Tlaxcala, a Tlaxcalan municipality in what is now the Mexican state of Coahuila
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