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Tra (gene)

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Gene For the T-cell receptor alpha locus gene, see TRA (gene).
Transformer
Identifiers
OrganismDrosophila melanogaster
Symboltra
Alt. symbolsCG16724; Dmel\CG16724; Dmtra
Entrez39849
RefSeq (mRNA)NM_079390.3
RefSeq (Prot)NP_524114.1
UniProtP11596
Other data
Chromosome3L: 16.58 - 16.58 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Protein family
Fruit fly transformer
Identifiers
SymbolTransformer
PfamPF06495
InterProIPR010519
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Alternative splicing of dsx pre-mRNA. Tra2 is a transformer protein; the gene is involved in the regulation of sex determination in many insects.
Transformer-2
Identifiers
OrganismDrosophila melanogaster
Symboltra2
UniProtP19018
Search for
StructuresSwiss-model
DomainsInterPro

Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.

The transformer protein controls female somatic sexual differentiation. The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.

References

  1. ^ Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. hdl:11370/2174764d-bd1b-4e1f-b142-90aced0c3e55. PMID 20570131. S2CID 205003182.
  2. Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872. S2CID 33918630.
  3. Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279. S2CID 20307555.
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