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Transformer (gene)

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Not to be confused with Transformer proteins.

Alternative splicing of the Drosophila Transformer gene product.
Protein family
Female-specific protein transformer
Identifiers
SymbolTra
PfamPF06495
InterProIPR010519
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Transformer
Identifiers
OrganismDrosophila melanogaster
Symboltra
Entrez39849
RefSeq (mRNA)NM_079390.3
RefSeq (Prot)NP_524114.1
UniProtP11596
Other data
Chromosome3L: 16.59 - 16.59 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Transformer 2
Identifiers
OrganismDrosophila melanogaster
Symboltra2
Entrez36619
RefSeq (mRNA)NM_057416.3
RefSeq (Prot)NP_476764.1
UniProtP19018
Other data
Chromosome2R: 14.6 - 14.6 Mb
Search for
StructuresSwiss-model
DomainsInterPro

Transformer (tra) is a family of genes which regulate sex determination in insects such as flies. Among its effects, it (P11596) regulates differences between males and females in Drosophila fruit flies.

The tra-2 gene (P19018) is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex.

References

  1. Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–383. doi:10.1016/j.gde.2010.05.001. hdl:11370/2174764d-bd1b-4e1f-b142-90aced0c3e55. PMID 20570131. S2CID 205003182.
  2. An X, Ota T, O'Neil MT, Steinmann-Zwicky M, Yamamoto D, et al. "tra - transformer". Gene Review. Nature Genetics. Archived from the original on 5 August 2021. Retrieved 7 December 2017.
  3. Rideout EJ, Narsaiya MS, Grewal SS (December 2015). "The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size". PLOS Genetics. 11 (12): e1005683. doi:10.1371/journal.pgen.1005683. PMC 4692505. PMID 26710087.
  4. Amrein H, Gorman M, Nöthiger R (December 1988). "The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein". Cell. 55 (6): 1025–1035. doi:10.1016/0092-8674(88)90247-4. PMID 3144434. S2CID 21183373.
  5. "Transformer-2 sex-determining protein". UniProt. Retrieved 7 December 2017.
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