Transient bullous dermolysis of the newborn

Medical condition

Transient bullous dermolysis of the newborn
Specialty	Dermatology

Transient bullous dermolysis of the newborn (TBDN) is a skin condition that presents in newborns. It is characterized by blister formation secondary to even mild trauma.

A subtype of dystrophic epidermolysis bullosa, it is rare, usually inherited condition that presents with characteristic blisters at birth which resolve between six months and one year of age.

Blisters may cover the entire body including the mouth, and as they heal, they may leave some mild scarring. In addition, nail changes may occur which can persist to adulthood.

It is associated with COL7A1.

The condition was described by Ken Hashimoto in 1985.

References

James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. S2CID 221861310.
^ "Transient bullous dermolysis of the newborn | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 11 August 2018.
Hammami-Hauasli N, Raghunath M, Küster W, Bruckner-Tuderman L (December 1998). "Transient bullous dermolysis of the newborn associated with compound heterozygosity for recessive and dominant COL7A1 mutations". J. Invest. Dermatol. 111 (6): 1214–9. doi:10.1046/j.1523-1747.1998.00394.x. PMID 9856844.
John Thorne Crissey; Lawrence C. Parish; Karl Holubar (2013). Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 179. ISBN 978-1-84214-100-7.
Murase, K; Kanoh, H; Ishii, N; Hashimoto, T; Nakano, H; Sawamura, D; Seishima, M (2011). "Bullous Dermolysis of the Newborn and Dystrophic Epidermolysis Bullosa Pruriginosa within the Same Family: Two Phenotypes Associated with a COL7A1 Mutation". Acta Dermato Venereologica. 91 (6): 730–731. doi:10.2340/00015555-1154. ISSN 0001-5555. PMID 21629976.

External links

Rare diseases-NIH

Classification	D ICD-11: EC32 ICD-10: Q81.2 OMIM: 131705 MeSH: C536979
External resources	Orphanet: 79411

Diseases of collagen, laminin and other scleroproteins

Collagen disease

COL1:	Osteogenesis imperfecta (types I–IV) Ehlers–Danlos syndrome (types 1, 2, & 7)
COL2:	Hypochondrogenesis Achondrogenesis (type 2) Stickler syndrome Marshall syndrome Spondyloepiphyseal dysplasia congenita Spondyloepimetaphyseal dysplasia, (Strudwick type) Kniest dysplasia (Type II collagenopathy)
COL3:	Ehlers–Danlos syndrome (types 3 & 4) Sack–Barabas syndrome
COL4:	Alport syndrome
COL5:	Ehlers–Danlos syndrome (types 1 & 2)
COL6:	Bethlem myopathy (type 1) Ullrich congenital muscular dystrophy (type 1)
COL7:	Epidermolysis bullosa dystrophica Recessive dystrophic epidermolysis bullosa Bart syndrome Transient bullous dermolysis of the newborn
COL8:	Fuchs' dystrophy (type 1)
COL9:	Multiple epiphyseal dysplasia (types 2, 3, & 6)
COL10:	Schmid metaphyseal chondrodysplasia
COL11:	Weissenbacher–Zweymüller syndrome Otospondylomegaepiphyseal dysplasia (Type XI collagenopathy)
COL12:	Bethlem myopathy (type 2) Ullrich congenital muscular dystrophy (type 2)
COL17:	Bullous pemphigoid
COL18:	Knobloch syndrome

Laminin

Other

see also fibrous proteins

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References

External links