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Tripchlorolide

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Tripchlorolide
Names

Preferred IUPAC name (3bS,4aS,5aS,6R,7R,8R,8aR,9aS,9bS)-8-Chloro-6,7-dihydroxy-9b-methyl-7-(propan-2-yl)-3b,4,4a,5a,6,7,8,8a,9a,9b,10,11-dodecahydrobis(oxireno)phenanthrofuran-1(3H)-one
Other names Triptolide chlorhydrin; Triptolide 12,13-chlorhydrin
Identifiers
CAS Number	132368-08-2
3D model (JSmol)	Interactive image
PubChem CID	159588
CompTox Dashboard (EPA)	DTXSID80927645
InChI InChI=1S/C20H25ClO6/c1-8(2)18(24)13(21)14-20(27-14)17(3)5-4-9-10(7-25-15(9)22)11(17)6-12-19(20,26-12)16(18)23/h8,11-14,16,23-24H,4-7H2,1-3H3/t11-,12-,13+,14-,16+,17-,18-,19+,20+/m0/s1Key: OIMACDABKWJVSQ-LZVGCMTRSA-N
SMILES CC(C)1((23(O2)4(CCC5=C(4C63(1O)O6)COC5=O)C)Cl)O
Properties
Chemical formula	C₂₀H₂₅ClO₆
Molar mass	396.86 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

Tripchlorolide is an isolate of Tripterygium wilfordii (雷公藤) that has potential interaction with the NMDA receptor.

References

Lin, N; Pan, XD; Chen, AQ; Zhu, YG; Wu, M; Zhang, J; Chen, XC (2013). "Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice". Behavioural Brain Research. 258C: 8–18. doi:10.1016/j.bbr.2013.10.010. PMID 24140565. S2CID 6173926.

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