Truffaut is a French surname that may refer to
- François Truffaut (1932–1984), French film director, screenwriter, producer, actor and critic
- François Truffaut Award
- Bibliothèque du cinéma François-Truffaut, a film library in Paris
- François Truffaut: Stolen Portraits, a 1993 French documentary film
- Hitchcock/Truffaut, a 1966 book by François Truffaut about Alfred Hitchcock
- Hitchcock/Truffaut (film), a 2015 French-American documentary film
- Rue François-Truffaut [fr], a street in the 12th arrondissement of Paris
- André Truffaut [fr] (born 1953), French footballer
- Éva Truffaut [fr] (born 1961), French actress and photographer; daughter of François Truffaut and Madeleine Morgenstern
- France Truffaut [fr] (1926–2014), Belgian politician
- Georges Truffaut [fr] (1872–1948), French gardener, founder of Jardineries Truffaut
- Georges Truffaut [fr] (1901–1942), Belgian politician
- Joanna Truffaut, French Digital transformation advisor and entrepreneur
- Pierre Truffaut [fr] (1894–1974), French politician
- Rue Truffaut [fr], a street in the 17th arrondissement of Paris
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