Tymazoline - Misplaced Pages

Chemical compound Pharmaceutical compound

Tymazoline
Clinical data

Trade names	Thymazen
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical (nasal solution)
ATC code	R01AA13 (WHO)
Identifiers
IUPAC name 2--4,5-dihydro-1H-imidazole
CAS Number	24243-97-8
PubChem CID	34154
DrugBank	DB08803
ChemSpider	31478
UNII	U993RH5585
KEGG	D07373
CompTox Dashboard (EPA)	DTXSID40178939
Chemical and physical data
Formula	C₁₄H₂₀N₂O
Molar mass	232.327 g·mol
3D model (JSmol)	Interactive image
SMILES Cc1ccc(c2c1cccc2OCC3=NCCN3)C(C)C
InChI InChI=1S/C14H20N2O/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16) Key:QRORCRWSRPKEHR-UHFFFAOYSA-N
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Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis. It acts as an antihistaminic and sympathomimetic, reducing swelling, inflammation and mucosal secretions.

References

Decongestants and other nasal preparations (R01)

Topical

Sympathomimetics, plain	Amidephrine Cyclopentamine Ephedrine Epinephrine Fenoxazoline Iproheptine Levmetamfetamine Methylephedrine Metizoline Naphazoline Oxymetazoline Phenylephrine Propylhexedrine Tetryzoline Tramazoline Tuaminoheptane Tymazoline Xylometazoline
Antiallergic agents, excluding corticosteroids	Spaglumic acid histamine antagonists (Levocabastine Antazoline Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid Nedocromil Azelastine Olopatadine Lodoxamide)
Corticosteroids	Beclometasone dipropionate Betamethasone Budesonide Ciclesonide Dexamethasone Flunisolide Fluticasone (Fluticasone furoate, Fluticasone propionate) Mometasone furoate Prednisolone Tixocortol Triamcinolone Triamcinolone acetonide
Other nasal preparations	Cafaminol Calcium hexamine thiocyanate Eucalyptus oil Framycetin Hexamidine Hyaluronan Ipratropium bromide Mupirocin Retinol Ritiometan Saline water
Combination products	Olopatadine/mometasone

Systemic use:
Sympathomimetics

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

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