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UCA1

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Non-coding RNA in the species Homo sapiens
UCA1
Identifiers
AliasesUCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36, urothelial cancer associated 1 (non-protein coding), urothelial cancer associated 1, UCA1 RNA, human
External IDsOMIM: 617500; GeneCards: UCA1; OMA:UCA1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for UCA1Genomic location for UCA1
Band19p13.12Start15,828,206 bp
End15,836,328 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endometrium

  • testicle

  • gallbladder

  • islet of Langerhans

  • placenta

  • urinary bladder

  • epithelium of colon

  • gonad

  • rectum

  • bone marrow
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

652995

n/a

Ensembl

ENSG00000214049

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 19: 15.83 – 15.84 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

In molecular biology, Urothelial cancer associated 1 (non-protein coding), also known as UCA1, is a long non-coding RNA, it is upregulated in bladder cancer. It is believed to function in regulation of embryonic development and in bladder cancer invasion and progression. It regulates the expression of several genes involved in tumourgenesis and/or embryonic development.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000214049 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006). "Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma" (PDF). Clinical Cancer Research. 12 (16): 4851–8. doi:10.1158/1078-0432.CCR-06-0134. PMID 16914571.
  4. Wang F, Li X, Xie X, Zhao L, Chen W (2008). "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion". FEBS Letters. 582 (13): 1919–27. doi:10.1016/j.febslet.2008.05.012. PMID 18501714. S2CID 207691688.

Further reading

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