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UFSP1
Identifiers
Aliases	UFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDs	OMIM: 611481; MGI: 1917490; HomoloGene: 80245; GeneCards: UFSP1; OMA:UFSP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,888,721 bp End 100,889,715 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G2|5 76.33 cM Start 137,292,891 bp End 137,293,927 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad muscle of thigh stromal cell of endometrium gastrocnemius muscle mucosa of transverse colon right adrenal cortex granulocyte left adrenal cortex skeletal muscle tissue right lobe of liver Top expressed in bone marrow quadriceps femoris muscle skeletal muscle tissue proximal tubule muscle of thigh thoracic diaphragm striatum of neuraxis neural layer of retina Hypothalamus muscle of arm More reference expression data BioGPS n/a
Gene ontology Molecular function UFM1 hydrolase activity cysteine-type peptidase activity molecular function Cellular component extracellular exosome Biological process proteolysis biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 402682 70240 Ensembl ENSG00000176125 ENSMUSG00000051502 UniProt Q6NVU6 Q9CZP0 RefSeq (mRNA) NM_001015072 NM_027356 RefSeq (protein) NP_001015072 NP_081632 Location (UCSC) Chr 7: 100.89 – 100.89 Mb Chr 5: 137.29 – 137.29 Mb PubMed search
Wikidata
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UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional..

References

1. ^ GRCh38: Ensembl release 89: ENSG00000176125 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000051502 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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