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UNC93A
Identifiers
Aliases	UNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDs	OMIM: 607995; MGI: 1933250; HomoloGene: 10356; GeneCards: UNC93A; OMA:UNC93A - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q27 Start 167,271,169 bp End 167,316,014 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A1|17 8.78 cM Start 13,327,504 bp End 13,350,697 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg secondary oocyte skin of abdomen right lobe of liver buccal mucosa cell duodenum rectum gallbladder human kidney metanephros Top expressed in jejunum spermatid esophagus duodenum placenta white adipose tissue colon ileum blastocyst testicle More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component membrane integral component of membrane plasma membrane Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54346 381058 Ensembl ENSG00000112494 ENSMUSG00000067049 UniProt Q86WB7 Q710D3 RefSeq (mRNA) NM_001143947 NM_018974 NM_199252 RefSeq (protein) NP_001137419 NP_061847 NP_954860 Location (UCSC) Chr 6: 167.27 – 167.32 Mb Chr 17: 13.33 – 13.35 Mb PubMed search
Wikidata
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Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans. It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.

UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in in vivo samples.

It is expressed in neurons, with staining close to the plasma membrane.

Read also for functional studies in C.elegans.

For you who are interested to read more about Unc93A in different species, see:

References

1. ^ GRCh38: Ensembl release 89: ENSG00000112494 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000067049 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Unc-93 homolog A (C. elegans)".
6. ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
7. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
8. ^ Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
9. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
10. Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
11. de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
12. Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.

Further reading

• Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.

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