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This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Uncoupling" neuropsychopharmacology – news · newspapers · books · scholar · JSTOR (February 2024) (Learn how and when to remove this message) This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-experts, without removing the technical details. (February 2021) (Learn how and when to remove this message) (Learn how and when to remove this message)

In neuropsychopharmacology, uncoupling, also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.

References

1. Mize, Amy L; Alpher, Richard H. "Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17(beta)-estradiol in vitro requires protein kinases A and C". Neuroendocrinology. ProQuest 220112648 – via ProQuest.
2. Ganguly, Prabarna; Holland, Freedom H; Brenhouse, Heather C. "Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress". Neuropsychopharmacology. ProQuest 1721699997.

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