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In enzymology, an ureidoglycolate hydrolase (EC 3.5.3.19) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + H₂O ${\displaystyle \rightleftharpoons }$ glyoxylate + 2 NH₃ + CO₂

Thus, the two substrates of this enzyme are (S)-ureidoglycolate and H₂O, whereas its 3 products are glyoxylate, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is (S)-ureidoglycolate amidohydrolase (decarboxylating). This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XSQ, 1XSR, 1YQC, and 2BDR.

References

• Winkler RG, Blevins DG, Randall DD (1988). "Ureide catabolism in soybeans. III. Ureidoglycolate amidohydrolase and allantoate amidohydrolase are activities of an allantoate degrading enzyme complex". Plant Physiol. 86 (4): 1084–1088. doi:10.1104/pp.86.4.1084. PMC 1054631. PMID 16666035.

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