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VSX2
Identifiers
Aliases	VSX2, CHX10, HOX10, MCOP2, MCOPCB3, RET1, visual system homeobox 2
External IDs	OMIM: 142993; MGI: 88401; HomoloGene: 7266; GeneCards: VSX2; OMA:VSX2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3 Start 74,239,449 bp End 74,262,738 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 D1|12 39.28 cM Start 84,616,536 bp End 84,642,231 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad lymph node C1 segment nucleus of brain substantia nigra subcutaneous adipose tissue Hypothalamus anterior pituitary Top expressed in neural layer of retina lens ciliary body corneal stroma inner nuclear layer iris lumbar subsegment of spinal cord epithelium of lens gastrula central gray substance of midbrain More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated response to stimulus visual perception regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338917 12677 Ensembl ENSG00000119614 ENSMUSG00000021239 UniProt P58304 Q61412 RefSeq (mRNA) NM_182894 NM_001301427 NM_007701 RefSeq (protein) NP_878314 NP_001288356 NP_031727 Location (UCSC) Chr 14: 74.24 – 74.26 Mb Chr 12: 84.62 – 84.64 Mb PubMed search
Wikidata
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Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119614 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021239 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
6. "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

Further reading

• Sanger Center, Washington University Genome Sequencing Center (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Ferda Percin E, Ploder LA, Yu JJ, Arici K, Horsford DJ, Rutherford A, et al. (August 2000). "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10". Nature Genetics. 25 (4): 397–401. doi:10.1038/78071. PMID 10932181. S2CID 9508022.
• Mikkola I, Bruun JA, Holm T, Johansen T (February 2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". The Journal of Biological Chemistry. 276 (6): 4109–4118. doi:10.1074/jbc.M008882200. PMID 11069920.
• Bar-Yosef U, Abuelaish I, Harel T, Hendler N, Ofir R, Birk OS (September 2004). "CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds". Human Genetics. 115 (4): 302–309. doi:10.1007/s00439-004-1154-2. PMID 15257456. S2CID 28981190.
• Dorval KM, Bobechko BP, Ahmad KF, Bremner R (March 2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1". The Journal of Biological Chemistry. 280 (11): 10100–10108. doi:10.1074/jbc.M412676200. PMID 15647262.
• Kuiper H, Spötter A, Williams JL, Distl O, Drögemüller C (2005). "Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34". Cytogenetic and Genome Research. 109 (4): 533. doi:10.1159/000084217. PMID 15909363.
• Dorval KM, Bobechko BP, Fujieda H, Chen S, Zack DJ, Bremner R (January 2006). "CHX10 targets a subset of photoreceptor genes". The Journal of Biological Chemistry. 281 (2): 744–751. doi:10.1074/jbc.M509470200. PMID 16236706.
• Faiyaz-Ul-Haque M, Zaidi SH, Al-Mureikhi MS, Peltekova I, Tsui LC, Teebi AS (August 2007). "Mutations in the CHX10 gene in non-syndromic microphthalmia/anophthalmia patients from Qatar". Clinical Genetics. 72 (2): 164–166. doi:10.1111/j.1399-0004.2007.00846.x. PMID 17661825. S2CID 6218901.

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