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VWA2
Identifiers
Aliases	VWA2, AMACO, CCSP-2, NET42, von Willebrand factor A domain containing 2, CCSP2
External IDs	OMIM: 618281; MGI: 2684334; HomoloGene: 18238; GeneCards: VWA2; OMA:VWA2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.3 Start 114,239,254 bp End 114,294,489 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 D2 Start 56,862,681 bp End 56,900,510 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus right uterine tube olfactory zone of nasal mucosa sural nerve testicle body of stomach fundus skin of abdomen body of pancreas skin of leg Top expressed in otic vesicle molar secondary oocyte primary oocyte lip tail of embryo proximal tubule genital tubercle cervix pulmonary alveolar epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding calcium ion binding Cellular component extracellular region basement membrane extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process calcium-independent cell-matrix adhesion protein homooligomerization regulation of insulin receptor signaling pathway growth plate cartilage chondrocyte morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340706 240675 Ensembl ENSG00000165816 ENSMUSG00000025082 UniProt Q5GFL6 Q70UZ7 RefSeq (mRNA) NM_001272046 NM_198496 NM_001320804 NM_172840 RefSeq (protein) NP_001258975 NP_001307733 NP_766428 Location (UCSC) Chr 10: 114.24 – 114.29 Mb Chr 19: 56.86 – 56.9 Mb PubMed search
Wikidata
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von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain. AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.

AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction, the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers; indicating that it might be a good candidate as a biomarker for this type of cancer.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000165816 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025082 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: von Willebrand factor A domain containing 2".
6. ^ Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The Journal of Biological Chemistry. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275.
7. Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (October 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biology. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.
8. Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (May 2014). "AMACO is a component of the basement membrane-associated Fraser complex". The Journal of Investigative Dermatology. 134 (5): 1313–1322. doi:10.1038/jid.2013.492. PMC 4361737. PMID 24232570.
9. Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene. 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307.

Further reading

• Eller E, Vardi P, Daly MJ, Babu S, Roberts C, Yang F, Eisenbarth GS, Fain PR (December 2004). "IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family". Annals of the New York Academy of Sciences. 1037 (1): 145–9. Bibcode:2004NYASA1037..145E. doi:10.1196/annals.1337.024. PMID 15699509. S2CID 41689175.
• Gebauer JM, Müller S, Hanisch FG, Paulsson M, Wagener R (June 2008). "O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein)". The Journal of Biological Chemistry. 283 (26): 17846–54. doi:10.1074/jbc.M704820200. PMID 18434322.

External links

• VWA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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