Vertefeuille is a surname. Notable people with the surname include:
- Christine S. Vertefeuille (born 1950), American lawyer and judge
- Fabien Vanasse dit Vertefeuille (1850–1936), Canadian journalist, lawyer and politician
- Jeanne Vertefeuille (1932–2012), CIA officer who investigated Cold War spy Aldrich Ames
See also
- Francois Vertefeuille House, historic house in Wisconsin, United States
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