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Vetispiradiene synthase (EC 4.2.3.21) is an enzyme from Egyptian henbane that catalyzes the following chemical reaction:

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ vetispiradiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming). Other names in common use include vetispiradiene-forming farnesyl pyrophosphate cyclase, pemnaspirodiene synthase, HVS, and vetispiradiene cyclase. This enzyme participates in terpenoid biosynthesis.

References

• Back K, Chappell J (1995). "Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases". J. Biol. Chem. 270 (13): 7375–81. doi:10.1074/jbc.270.13.7375. PMID 7706281.
• Chappell J, Ricci P, Marco Y (1998). "Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco". Planta. 205 (3): 467–476. doi:10.1007/s004250050345.
• Mathis JR, Back K, Starks C, Noel J, Poulter CD, Chappell J (1997). "Pre-steady-state study of recombinant sesquiterpene cyclases". Biochemistry. 36 (27): 8340–8. doi:10.1021/bi963019g. PMID 9204881.
• Yoshioka H, Yamada N, Doke N (1999). "cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans". Plant Cell Physiol. 40 (9): 993–8. PMID 10588069.
• Martin VJ, Yoshikuni Y, Keasling JD (2001). "The in vivo synthesis of plant sesquiterpenes by Escherichia coli". Biotechnol. Bioeng. 75 (5): 497–503. doi:10.1002/bit.10037. PMID 11745124.

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