| Virginia Papaioannou | |
|---|---|
| Born | Virginia Vann |
Virginia E. Papaioannou is a developmental biologist, recognized for who works in mammalian genetics. She is a Special Lecturer and Professor Emerita in the Department of Genetics and Development at Columbia University Irving Medical Center.
Education and career
Papaioannou grew up in Ukiah, California. She earned her B.S. in Biological Sciences from the University of California, Davis in 1968 and her Ph.D. in Genetics from Cambridge University in 1972.
Research
Throughout her career, she has focused on the genetic control of early mammalian development, from the first cleavage of the fertilized zygote through implantation, gastrulation, and early organogenesis. Papaioannou has extensively studied the T-box gene family, which plays a crucial role in mesoderm formation and organogenesis. Her research led to significant insights into developmental birth defects, producing mouse models for human syndromes such as DiGeorge syndrome (TBX1) and ulnar mammary syndrome (TBX3). Her work has been important for understanding how these genes control cell fate and tissue specification during early development.
Selected publications
- Papaioannou, V. E.; Mcburney, M. W.; Gardner, R. L.; Evans, M. J. (1975). "Fate of teratocarcinoma cells injected into early mouse embryos". Nature. 258 (5530): 70–73. Bibcode:1975Natur.258...70P. doi:10.1038/258070a0. ISSN 0028-0836. PMID 1186881.
- Mombaerts, Peter; Iacomini, John; Johnson, Randall S.; Herrup, Karl; Tonegawa, Susumu; Papaioannou, Virginia E. (1992-03-06). "RAG-1-deficient mice have no mature B and T lymphocytes". Cell. 68 (5): 869–877. doi:10.1016/0092-8674(92)90030-G. ISSN 0092-8674. PMID 1547488.
- Papaioannou, Virginia E.; Silver, Lee M. (1998). "The T-box gene family". BioEssays. 20 (1): 9–19. doi:10.1002/(SICI)1521-1878(199801)20:1<9::AID-BIES4>3.0.CO;2-Q. ISSN 1521-1878. PMID 9504043.
- Jerome, Loydie A.; Papaioannou, Virginia E. (2001). "DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1". Nature Genetics. 27 (3): 286–291. doi:10.1038/85845. ISSN 1061-4036. PMID 11242110.
Honors and awards
Her contributions have been recognized with several honors, including the NIH MERIT award and the Dean's Distinguished Lecture in the Basic Sciences at Columbia University.
References
- ^ "Research scientists visit their family in Ukiah". Ukiah Daily Journal. 1973-08-28. p. 4. Retrieved 2024-12-20.
- ^ "Virginia E. Papaioannou, PhD". Vagelos College of Physicians and Surgeons. 2017-06-12. Retrieved 2024-12-20.
- Papaioannou, Virginia E. (2014-10-15). "The T-box gene family: emerging roles in development, stem cells and cancer". Development. 141 (20): 3819–3833. doi:10.1242/dev.104471. ISSN 0950-1991. PMC 4197708. PMID 25294936.
- Jerome, Loydie A.; Papaioannou, Virginia E. (2001). "DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1". Nature Genetics. 27 (3): 286–291. doi:10.1038/85845. ISSN 1061-4036. PMID 11242110.
- Davenport, Todd G.; Jerome-Majewska, Loydie A.; Papaioannou, Virginia E. (2003-05-15). "Mammary gland, limb and yolk sac defects in mice lacking Tbx3,the gene mutated in human ulnar mammary syndrome". Development. 130 (10): 2263–2273. doi:10.1242/dev.00431. ISSN 0950-1991. PMID 12668638.
External links
- Virginia Papaioannou publications indexed by Google Scholar
- Appearances on C-SPAN, January 9, 2001, Papaioannou spoke on human cloning research