Misplaced Pages

8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase. This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)

(2) S-adenosyl-L-methionine + xanthotoxol ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + xanthotoxin

8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol into xanthotoxin.

References

1. Thompson HJ, Sharma SK, Brown SA (June 1978). "O-methyltransferases of furanocoumarin biosynthesis". Archives of Biochemistry and Biophysics. 188 (2): 272–81. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
2. Hauffe, K.D.; Hahlbrock, K.; Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Zeitschrift für Naturforschung C. 41: 228–239. doi:10.1515/znc-1986-1-234.
3. Sharma SK, Garrett JM, Brown SA (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Zeitschrift für Naturforschung C. 34 (5–6): 387–91. doi:10.1515/znc-1979-5-611. PMID 156999.
4. Hehmann M, Lukacin R, Ekiert H, Matern U (March 2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". European Journal of Biochemistry. 271 (5): 932–40. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.

External links

• 8-hydroxyfuranocoumarin+8-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

This enzyme-related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• EC 2.1.1
• Coumarins metabolism
• Enzyme stubs