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ZEB2-AS1

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ZEB2-AS1
Identifiers
AliasesZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT, ZEB2 antisense RNA 1
External IDsGeneCards: ZEB2-AS1; OMA:ZEB2-AS1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for ZEB2-AS1Genomic location for ZEB2-AS1
Band2q22.3Start144,517,978 bp
End144,521,477 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • corpus callosum

  • bone marrow cells

  • Achilles tendon

  • testicle

  • C1 segment

  • epithelium of colon

  • sural nerve

  • substantia nigra
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

100303491

n/a

Ensembl

ENSG00000238057

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 2: 144.52 – 144.52 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene. It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000238057 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K (October 2003). "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics. 82 (4): 460–469. doi:10.1016/S0888-7543(03)00169-1. PMID 13679026.
  4. ^ Beltran M, Puig I, Peña C, et al. (March 2008). "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev. 22 (6): 756–769. doi:10.1101/gad.455708. PMC 2275429. PMID 18347095.

Further reading

External links

Gallery of ZEB2-AS1 conserved RNA secondary structure images
  • ZEB2_AS1_1: Secondary structure taken from the Rfam database. Family RF01984 ZEB2_AS1_1: Secondary structure taken from the Rfam database. Family RF01984
  • ZEB2_AS1_2: Secondary structure taken from the Rfam database. Family RF01985 ZEB2_AS1_2: Secondary structure taken from the Rfam database. Family RF01985
  • ZEB2_AS1_3: Secondary structure taken from the Rfam database. Family RF01986 ZEB2_AS1_3: Secondary structure taken from the Rfam database. Family RF01986
  • ZEB2_AS1_4: Secondary structure taken from the Rfam database. Family RF01987 ZEB2_AS1_4: Secondary structure taken from the Rfam database. Family RF01987
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