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{{Short description|Chemical compound}}
{{unreferenced|date=February 2010}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
⚫ | IUPAC_name = 4-(2-bromo-4,5-dimethoxybenzyl)-4-(2-heptan-2-yl)ethoxy]ethyl)morpholin-4-ium
| Watchedfields = changed
⚫ | image = pinaverium.png
| verifiedrevid = 448202349
⚫ | CAS_number = 59995-65-2
⚫ | IUPAC_name = 4--4-heptanyl)ethoxy]ethyl]morpholin-4-ium bromide
⚫ | ATC_prefix = A03
⚫ | image = pinaverium bromide.svg
⚫ | ATC_suffix = AX04

⚫ | PubChem = 40704
<!--Clinical data-->
⚫ | DrugBank =
| tradename =
⚫ | C=26|H=41|Br=1|N=1|O=4
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| molecular_weight = 511.51 g/mol
| pregnancy_US = <!-- A / B / C / D / X -->
⚫ | bioavailability =
⚫ | pregnancy_category =
⚫ | protein_bound =
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| metabolism =
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | elimination_half-life =
| excretion = | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | routes_of_administration =
⚫ | pregnancy_category=

⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
<!--Pharmacokinetic data-->
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | bioavailability =
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | protein_bound =
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = | metabolism =
⚫ | elimination_half-life =
⚫ | routes_of_administration =
| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|CAS}}
⚫ | CAS_number = 53251-94-8
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 7SCF54H12J
⚫ | ATC_prefix = A03
⚫ | ATC_suffix = AX04
⚫ | PubChem = 40703
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫ | DrugBank = DBSALT001130
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 37181
| smiles = CC1(C2CCC(C1C2)CCOCC3(CCOCC3)Cc4cc(c(cc4Br)OC)OC)C.
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = IKGXLCMLVINENI-UHFFFAOYSA-M

<!--Chemical data-->
⚫ | C=26 | H=41 | Br=2 | N=1 | O=4
}} }}


'''Pinaverium bromide''' (]) is a medication used for ]s. It belongs to a drug group called ]s and acts as a ] in helping to restore the normal contraction process of the bowel. It is most effective when taken for a full course of treatment and is not designed for immediate symptom relief or sporadic, intermittent use.<ref>{{cite book | vauthors = | chapter = Trimebutine Maleate and Pinaverium Bromide for Irritable Bowel Syndrome: A Review of the Clinical Effectiveness, Safety and Guidelines . | title = CADTH Rapid Response Reports | location = Ottawa (ON) | publisher = Canadian Agency for Drugs and Technologies in Health | date = November 2015 | pmid = 26985535 | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK350043/ }}</ref>
'''Pinaverium''' is a drug used for ]s. It acts as a ].


Pinaverium bromide was first registered in 1975 by ] (now a division of ]), and marketed globally using the brand names '''Dicetel''' and '''Eldicet'''. Generic pinaverium is available in South Korea under a trade name of '''Disten'''<ref>{{cite web | url = http://www.kmle.co.kr/viewDrug.php?m=%B6%F3%BD%C4&inx=26702&c=afdf17b8b3cde357bf3163dd78dbc00f | work = KMLE | title = Drug/Drug Information: Disten Tablet | language = ko | access-date = 2016-03-07 | archive-date = 2018-09-20 | archive-url = https://web.archive.org/web/20180920111710/http://www.kmle.co.kr/viewDrug.php?m=%B6%F3%BD%C4&inx=26702&c=afdf17b8b3cde357bf3163dd78dbc00f | url-status = dead }}</ref> and in Argentina as '''Nulite'''.<ref>{{Cite web | url=http://www.labdominguez.com.ar/es/productos/28-nulite | title=NULITE | work=Laboratorio Dominguez | access-date=2017-07-03 | archive-date=2019-08-24 | archive-url=https://web.archive.org/web/20190824084406/http://www.labdominguez.com.ar/es/productos/28-nulite | url-status=dead }}</ref>

==Indications==
It is indicated for the treatment and relief of symptoms associated with ] (IBS) including abdominal pain, bowel disturbances and intestinal discomfort; and treatment of symptoms related to functional disorders of biliary tract.<ref>{{Cite book|author=Abbott Laboratories |title=Dicetel Product Insert/Information Malaysia| date=Feb 2012 }}</ref>

==References==
{{Reflist}}


{{Drugs for functional gastrointestinal disorders}} {{Drugs for functional gastrointestinal disorders}}
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] ]
] ]
]
] ]
] ]
] ]
]


{{gastrointestinal-drug-stub}}
{{antihypertensive-stub}}

Latest revision as of 16:59, 15 September 2024

Chemical compound Pharmaceutical compound
Pinaverium bromide
Clinical data
ATC code
Identifiers
IUPAC name
  • 4--4-heptanyl)ethoxy]ethyl]morpholin-4-ium bromide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H41Br2NO4
Molar mass591.425 g·mol
3D model (JSmol)
SMILES
  • CC1(C2CCC(C1C2)CCOCC3(CCOCC3)Cc4cc(c(cc4Br)OC)OC)C.
InChI
  • InChI=1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1
  • Key:IKGXLCMLVINENI-UHFFFAOYSA-M
  (what is this?)  (verify)

Pinaverium bromide (INN) is a medication used for functional gastrointestinal disorders. It belongs to a drug group called antispasmodics and acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel. It is most effective when taken for a full course of treatment and is not designed for immediate symptom relief or sporadic, intermittent use.

Pinaverium bromide was first registered in 1975 by Solvay Pharmaceuticals (now a division of Abbott Laboratories), and marketed globally using the brand names Dicetel and Eldicet. Generic pinaverium is available in South Korea under a trade name of Disten and in Argentina as Nulite.

Indications

It is indicated for the treatment and relief of symptoms associated with irritable bowel syndrome (IBS) including abdominal pain, bowel disturbances and intestinal discomfort; and treatment of symptoms related to functional disorders of biliary tract.

References

  1. "Trimebutine Maleate and Pinaverium Bromide for Irritable Bowel Syndrome: A Review of the Clinical Effectiveness, Safety and Guidelines [Internet].". CADTH Rapid Response Reports. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. November 2015. PMID 26985535.
  2. "Drug/Drug Information: Disten Tablet". KMLE (in Korean). Archived from the original on 2018-09-20. Retrieved 2016-03-07.
  3. "NULITE". Laboratorio Dominguez. Archived from the original on 2019-08-24. Retrieved 2017-07-03.
  4. Abbott Laboratories (Feb 2012). Dicetel Product Insert/Information Malaysia.
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