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N-Propyl azide: Difference between revisions

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{{DISPLAYTITLE:''n''-Propyl azide}} {{DISPLAYTITLE:''n''-Propyl azide}}
{{chembox {{chembox
| Verifiedfields = changed
| Watchedfields = changed | Watchedfields = changed
| verifiedrevid = 411102772 | verifiedrevid = 420919817
| Name = ''n''-Propyl azide | Name = ''n''-Propyl azide
| ImageFile = Propyl azide.svg | ImageFile = Propyl azide.svg
| ImageAlt = Skeletal formula of propyl azide
| ImageSize =
| ImageFile1 = Propyl-azide-3D-balls.png
| IUPACName = 1-Azidopropane
| ImageSize1 = 190
| ImageAlt1 = Ball-and-stick model of the propyl azide molecule
| PIN = 1-Azidopropane
| OtherNames = | OtherNames =
| Section1 = {{Chembox Identifiers |Section1={{Chembox Identifiers
| CASNo =22293-25-0 | CASNo =22293-25-0
| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| PubChem = | PubChem = 12405072
| SMILES ===NCCC | SMILES ===NCCC
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 14073926
| InChI = 1/C3H7N3/c1-2-3-5-6-4/h2-3H2,1H3
| InChIKey = TVPPZASKIXGUJQ-UHFFFAOYAK
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C3H7N3/c1-2-3-5-6-4/h2-3H2,1H3
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = TVPPZASKIXGUJQ-UHFFFAOYSA-N

}} }}
| Section2 = {{Chembox Properties |Section2={{Chembox Properties
| C=3 | H=7 | N=3 | C=3 | H=7 | N=3
| Appearance = | Appearance =
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| SolubleOther = | SolubleOther =
}} }}
| Section3 = {{Chembox Explosive |Section3={{Chembox Explosive
| ShockSens = | ShockSens =
| FrictionSens = | FrictionSens =
| ExplosiveV = | DetonationV =
| REFactor = }} | REFactor = }}
| Section4 = {{Chembox Hazards |Section4={{Chembox Hazards
| MainHazards = Harmful, Explosive | MainHazards = Harmful, Explosive
| FlashPt = | FlashPt =
| Autoignition = }} | AutoignitionPt = }}
| Section8 = {{Chembox Related |Section8={{Chembox Related
| OtherAnions = | OtherAnions =
| OtherCations = | OtherCations =
| OtherFunctn = | OtherFunction =
| Function = | OtherFunction_label =
| OtherCpds = ], ], ] }} | OtherCompounds = ], ], ] }}
}} }}


'''''n''-Propyl azide''' is an ] with the formula CH<sub>3</sub>CH<sub>2</sub>CH<sub>2</sub>N<sub>3</sub>. A white solid, it is a simple ].
'''''n''-Propyl azide''' is a covalent molecule related to ] and other ]s.<ref>Stefan Bräse (Editor), Klaus Banert (Co-Editor); ''Organic Azides: Syntheses and Applications''; 2010 ]; ISBN 978-0-470-51998-1</ref> <ref>Stefan Bräse (Editor), Klaus Banert (Co-Editor); ''Organic Azides: Syntheses and Applications''; 2010 ]; {{ISBN|978-0-470-51998-1}}</ref>


''n''-Propyl azide has been used in the laboratory synthesis of pharmaceutical drug candidates.<ref>{{Cite journal | author = Helmut Haning ''et al'' | title = Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors | journal = ] | year = 2005 | volume = 15 | issue = 17 | pages = 3900–3907}}</ref><ref>{{cite journal | author = Michael H. Parker ''et al'' | title = Synthesis of (-)-5,8-Dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: An Inhibitor of β-Amyloid<sub>1-42</sub> Aggregation | journal = ] | year = 2002 | volume = 10 | issue = 11 | pages = 3565–3569}}</ref> ''n''-Propyl azide has been used in the laboratory synthesis of pharmaceutical drug candidates.<ref>{{Cite journal | author = Helmut Haning| title = Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors | journal = ] | year = 2005 | volume = 15 | issue = 17 | pages = 3900–3907 | doi=10.1016/j.bmcl.2005.05.090| pmid = 15993055 |display-authors=etal}}</ref><ref>{{cite journal | author = Michael H. Parker| title = Synthesis of ()-5,8-Dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: An Inhibitor of β-Amyloid<sub>1-42</sub> Aggregation | journal = ] | year = 2002 | volume = 10 | issue = 11 | pages = 3565–3569 | doi=10.1016/s0968-0896(02)00251-1|display-authors=etal | pmid=12213471}}</ref>


==References== ==References==
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==Further reading== ==Further reading==
* {{cite journal | author = Edward J. Kaufmann, Richard C. Thompson | title = Reduction of organic azides by chromium(II) in aqueous solution | journal = ] | year = 1977 | volume = 99 | issue = 6 | pages = 1824–1830 | doi = 10.1021/ja00448a025}} * {{cite journal | author = Edward J. Kaufmann, Richard C. Thompson | title = Reduction of organic azides by chromium(II) in aqueous solution | journal = ] | year = 1977 | volume = 99 | issue = 6 | pages = 1824–1830 | doi = 10.1021/ja00448a025}}


{{DEFAULTSORT:Propyl azide, n-}} {{DEFAULTSORT:Propyl azide, n-}}
] ]
]





Latest revision as of 07:36, 19 July 2023

n-Propyl azide
Skeletal formula of propyl azide
Ball-and-stick model of the propyl azide molecule
Names
Preferred IUPAC name 1-Azidopropane
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C3H7N3/c1-2-3-5-6-4/h2-3H2,1H3Key: TVPPZASKIXGUJQ-UHFFFAOYSA-N
  • InChI=1/C3H7N3/c1-2-3-5-6-4/h2-3H2,1H3Key: TVPPZASKIXGUJQ-UHFFFAOYAK
SMILES
  • ==NCCC
Properties
Chemical formula C3H7N3
Molar mass 85.110 g·mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards Harmful, Explosive
Related compounds
Related compounds Hydrazoic acid, Chlorine azide, Ethyl azide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒verify (what is  ?) Infobox references
Chemical compound

n-Propyl azide is an organic compound with the formula CH3CH2CH2N3. A white solid, it is a simple organic azide.

n-Propyl azide has been used in the laboratory synthesis of pharmaceutical drug candidates.

References

  1. Stefan Bräse (Editor), Klaus Banert (Co-Editor); Organic Azides: Syntheses and Applications; 2010 John Wiley and Sons; ISBN 978-0-470-51998-1
  2. Helmut Haning; et al. (2005). "Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors". Bioorganic & Medicinal Chemistry Letters. 15 (17): 3900–3907. doi:10.1016/j.bmcl.2005.05.090. PMID 15993055.
  3. Michael H. Parker; et al. (2002). "Synthesis of (−)-5,8-Dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: An Inhibitor of β-Amyloid1-42 Aggregation". Bioorganic & Medicinal Chemistry. 10 (11): 3565–3569. doi:10.1016/s0968-0896(02)00251-1. PMID 12213471.

Further reading


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