Nitroxoline: Difference between revisions

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Revision as of 18:47, 24 June 2012

Pharmaceutical compound

Nitroxoline
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	J01XX07 (WHO)
Identifiers
IUPAC name 5-nitroquinolin-8-ol
CAS Number	4008-48-4
PubChem CID	19910
DrugBank	DB01422
ChemSpider	18756
UNII	A8M33244M6
KEGG	D07245
ChEMBL	ChEMBL1454910
CompTox Dashboard (EPA)	DTXSID4046284
ECHA InfoCard	100.021.513
Chemical and physical data
Formula	C₉H₆N₂O₃
Molar mass	190.156 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES (=O)c1ccc(O)c2ncccc12
InChI InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H Key:RJIWZDNTCBHXAL-UHFFFAOYSA-N
(what is this?) (verify)

Nitroxoline is an antibiotic.

It was recently discovered that nitroxoline has antiangiogenic properties, which could make it useful as an anti-cancer drug.

Pelletier C, Prognon P, Bourlioux P (1995). "Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains". Antimicrob. Agents Chemother. 39 (3): 707–13. PMC 162609. PMID 7793877.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Joong Sup Shim, Yoshiyuki Matsui, Shridhar Bhat, Benjamin A. Nacev, Jing Xu, Hyo-eun C. Bhang, Surajit Dhara, Kee Chung Han, Curtis R. Chong, Martin G. Pomper, Alan So Jun O. Liu (2010). "Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer". J Natl Cancer Inst. 102 (24): 1855–1873. doi:10.1093/jnci/djq457. PMC 3001967. PMID 21088277.{{cite journal}}: CS1 maint: multiple names: authors list (link)

v t e Antibacterials: others (J01X, D06AX)
Glycopeptides Lipoglycopeptides	Avoparcin Corbomycin Dalbavancin Oritavancin Ristocetin Teicoplanin Telavancin Vancomycin
Polymyxins	Colistin Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole Ornidazole Tinidazole
Pleuromutilins	Azamulin Lefamulin Retapamulin Tiamulin Valnemulin
Nitrofuran derivatives	Furazolidone Nifuroxazide Nifurtoinol Nifurzide Nitrofurantoin Nitrofurazone
Other antibacterials	Bacitracin Clofoctol Daptomycin Fosfomycin Furaltadone Lefamulin Linezolid Mandelic acid Methenamine Nitroxoline Novobiocin Spectinomycin Tedizolid Xibornol

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