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Evodiamine

Clinical data
ATC code	none
Identifiers
IUPAC name 21-methyl-3,13,21-triazapentacyclohenicosa-2(10),4,6,8,15,17,19-heptaen-14-one
CAS Number	518-17-2
PubChem CID	151289
ChemSpider	133343
CompTox Dashboard (EPA)	DTXSID10966123
ECHA InfoCard	100.164.846
Chemical and physical data
Formula	C19H17N3O
Molar mass	303.36 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=C4N3CCc2c(nc1ccccc12)C3N(c5ccccc45)C
InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3 Key:TXDUTHBFYKGSAH-UHFFFAOYSA-N

Evodiamine is a chemical which is extracted from the Evodia spp family of plants which has been shown to reduce fat uptake in mouse studies. Its method is believed to be similar to capsaicin, but retains none of the "hot" taste.

References

• Kobayashi, Y. et al. (2001): Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. In: Planta Med. 67(7); 628–33; PMID 11582540
• Wang, T. et al. (2008): Evodiamine improves diet-induced obesity in an uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. In: Endocrinology 149(1); 358–66; PMID 17884939

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