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Nitroxoline

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This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 19:40, 21 October 2011 (Updating {{drugbox}} (changes to verified and watched fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 19:40, 21 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified and watched fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Nitroxoline
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 5-nitroquinolin-8-ol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.021.513 Edit this at Wikidata
Chemical and physical data
FormulaC9H6N2O3
Molar mass190.156 g/mol g·mol
3D model (JSmol)
SMILES
  • (=O)c1ccc(O)c2ncccc12
InChI
  • InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
  • Key:RJIWZDNTCBHXAL-UHFFFAOYSA-N
  (what is this?)  (verify)

Nitroxoline is an antibiotic.

It was recently discovered that nitroxoline has antiangiogenic properties, which could make it useful as an anti-cancer drug.

References

  1. Pelletier C, Prognon P, Bourlioux P (1995). "Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains". Antimicrob. Agents Chemother. 39 (3): 707–13. PMC 162609. PMID 7793877.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. Joong Sup Shim, Yoshiyuki Matsui, Shridhar Bhat, Benjamin A. Nacev, Jing Xu, Hyo-eun C. Bhang, Surajit Dhara, Kee Chung Han, Curtis R. Chong, Martin G. Pomper, Alan So Jun O. Liu (2010). "Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer". J Natl Cancer Inst. 102 (24): 1855–1873. doi:10.1093/jnci/djq457. PMC 3001967. PMID 21088277.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Antibacterials: others (J01X, D06AX)
Glycopeptides
Lipoglycopeptides
Polymyxins
Steroid antibacterials
Imidazole derivatives
Pleuromutilins
Nitrofuran derivatives
Other antibacterials
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