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Revision as of 15:54, 6 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 444151762 of page Sodium_salicylate for the Chem/Drugbox validation project (updated: 'ChEMBL', 'KEGG').  Latest revision as of 05:42, 23 November 2024 edit ChemicalBear (talk | contribs)Extended confirmed users663 edits Rescuing 4 sources and tagging 0 as dead.) #IABot (v2.0.9.5Tag: IABotManagementConsole [1.3] 
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}}
{{chembox {{chembox
| Verifiedfields = changed
⚫ | verifiedrevid = 401613201
| Watchedfields = changed
| ImageFile = SodiumSalicylate.png
⚫ | verifiedrevid = 476997079
⚫ | ImageSize =
| IUPACName = Sodium salicylate | ImageFile = Sodium salicylate2DCSD.svg
⚫ | ImageSize = 100px
⚫ | OtherNames = Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin, [http://ChEMBL = 447868
| PIN = Sodium 2-hydroxybenzoate
⚫ | PubChem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5900&ncount=51#Synonyms ...]
⚫ | OtherNames = Salsonin, Monosodium salicylate, Sodium ''o''-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
| Section1 = {{Chembox Identifiers |Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5689 | ChemSpiderID = 5689
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
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| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 54-21-7 | CASNo = 54-21-7
| EINECS = 200-198-0 | EINECS = 200-198-0
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 447868
| PubChem = 5900 | ChEMBL = 447868
| DrugBank = DB01398 | PubChem = 16760658
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01398
| SMILES = .O=C()c1ccccc1O | SMILES = .O=C()c1ccccc1O
| InChI = 1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m | InChI = 1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = <!-- blanked - oldvalue: D00566 -->
| RTECS = VO5075000 | KEGG = D00566
| RTECS = VO5075000
}} }}
| Section2 = {{Chembox Properties |Section2={{Chembox Properties
| C=7 | H=5 | Na=1 | O=3
| Formula = C<sub>7</sub>H<sub>5</sub>NaO<sub>3</sub>
| MolarMass = 160.11 g/mol | MolarMassUnit = g/mol
| Appearance = White crystals | Appearance = White crystals
| Density = | Density =
| MeltingPt = 200 °C | MeltingPtC = 200
| BoilingPt = | BoilingPt =
| Solubility = 25.08{{nbsp}}g/100{{nnbsp}}g (-1.5{{nbsp}}°C)<br> 107.9{{nbsp}}g/100{{nnbsp}}g (15{{nbsp}}°C)<br> 124.6{{nbsp}}g/100{{nnbsp}}g (25{{nbsp}}°C)<br> 141.8{{nbsp}}g/100{{nnbsp}}g (78.5{{nbsp}}°C)<br> 179{{nbsp}}g/100{{nnbsp}}g (114{{nbsp}}°C)<ref name=chemister>{{cite web|url=http://chemister.ru/Database/properties-en.php?dbid=1&id=2993|title=sodium salicylate|website=chemister.ru|access-date=8 April 2018|archive-date=24 May 2014|archive-url=https://web.archive.org/web/20140524024107/http://chemister.ru/Database/properties-en.php?dbid=1&id=2993|url-status=live}}</ref>
| Solubility = ~ 660 g/l at 20 °C
| SolubleOther = Soluble in ], ], ]<ref name=chemister />
| Solubility1 = 26.28{{nbsp}}g/100{{nnbsp}}g (15{{nbsp}}°C)<br> 34.73{{nbsp}}g/100{{nnbsp}}g (67.2{{nbsp}}°C)<ref name=chemister />
| Solvent1 = methanol
}} }}
| Section3 = {{Chembox Hazards |Section6={{Chembox Pharmacology
| ATCCode_prefix = N02
⚫ | MainHazards = Harmful
| FlashPt = | ATCCode_suffix = BA04
}}
| Autoignition = > 250 °C
|Section7={{Chembox Hazards
⚫ | NFPA-H = 1
| GHSPictograms = {{GHS07}}
⚫ | NFPA-F = 1
| GHS_ref = <ref name="sigma">], . Retrieved on 2014-05-26.</ref>
⚫ | NFPA-R = 0
| GHSSignalWord = Warning
⚫ | NFPA-O =
| RPhrases = {{R22}}, {{R36/37/38}} | HPhrases = {{H-phrases|314|331|400}}
| PPhrases = {{P-phrases|210|261|273|280|305+351+338|310}}
| SPhrases = {{S24/25}}, {{S26}}, {{S36/37/39}}
⚫ | MainHazards = Harmful
| EyeHazard = Irritant
| FlashPt =
| AutoignitionPtC = 250
⚫ | NFPA-H = 1
⚫ | NFPA-F = 1
⚫ | NFPA-R = 0
⚫ | NFPA-S =
| LD50 = 930 mg/kg (rats, oral)<ref>{{cite web|url=https://chem.nlm.nih.gov/chemidplus/rn/54-21-7|title=ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA-M - Sodium salicylate - Similar structures search, synonyms, formulas, resource links, and other chemical information.|first=Michael|last=Chambers|website=chem.sis.nlm.nih.gov|access-date=8 April 2018|archive-date=9 April 2018|archive-url=https://web.archive.org/web/20180409171616/https://chem.nlm.nih.gov/chemidplus/rn/54-21-7|url-status=live}}</ref>
}} }}
}} }}

'''Sodium salicylate''' is a ] salt of ]. It can be prepared from ] and ] under higher temperature and pressure. Historically, it has been synthesized by refluxing ] (] oil) with an excess of ].<ref>Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009</ref>

==Properties==
{{Expand section|date=July 2024}}
Sodium salicylate is of the ] family. It is a shiny white powder with an aromatic taste.<ref>{{Cite web |title=Sodium salicylate {{!}} 54-21-7 |url=https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |access-date=2024-09-02 |website=ChemicalBook |language=en |archive-date=2024-09-02 |archive-url=https://web.archive.org/web/20240902235509/https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |url-status=live }}</ref>

==Uses==
It is used in medicine as an ] and ].<ref>{{Cite web |title=Sodium salicylate {{!}} 54-21-7 |url=https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |access-date=2024-09-02 |website=ChemicalBook |language=en |archive-date=2024-09-02 |archive-url=https://web.archive.org/web/20240902235509/https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |url-status=live }}</ref> Sodium salicylate also acts as ] (NSAID), and induces ] in cancer cells <ref>{{cite journal | title = Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines | journal = Blood | date = 1999-04-01 | first = Lidija | last = Klampfer |author2=Jörg Cammenga |author3=Hans-Georg Wisniewski |author4=Stephen D. Nimer | volume = 93 | issue = 7 | pages = 2386–94| doi = 10.1182/blood.V93.7.2386 | pmid=10090950}}</ref><ref>{{cite journal | title = Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis | journal = Proceedings of the National Academy of Sciences of the USA | date = 2007-07-31 | first = Colin | last = Rae |author2=Susana Langa |author3=Steven J. Tucker |author4=David J. MacEwan | volume = 104 | issue = 31 | pages = 12790–5| pmid=17646662 | pmc = 1937545 | doi=10.1073/pnas.0701437104| bibcode = 2007PNAS..10412790R | doi-access = free }}</ref><ref>{{cite journal | title = Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer | journal = Carcinogenesis | date = May 2007 | first = Lesley A. | last = Stark | volume = 28 | issue = 5 | pages = 968–76| pmid=17132819 | doi=10.1093/carcin/bgl220|display-authors=etal| doi-access = free }}</ref> and also ].<ref>{{cite journal | title = Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate | journal = The Journal of Biological Chemistry | date = 1996-04-05 | first = Paul | last = Schwenger |author2=Edward Y. Skolnik |author3=Jan Vilcek | volume = 271 | issue = 14 | pages = 8089–94| pmid=8626494 | doi=10.1074/jbc.271.14.8089| doi-access = free }}</ref> It is also a potential replacement for ] for people sensitive to it. It may also be used as a phosphor for the detection of ] radiation and ].<ref>{{cite web|last=Samson|first=James|title=Vacuum Ultraviolet Spectroscopy|url=http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf|publisher=Pied Publications|access-date=July 26, 2012|url-status=dead|archive-url=https://web.archive.org/web/20061016104429/http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf|archive-date=October 16, 2006}}</ref>

==References==
{{reflist}}

== External links ==
{{Commons category}}
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* {{Webarchive|url=https://web.archive.org/web/20060523222443/http://physchem.ox.ac.uk/MSDS/SO/sodium_salicylate.html |date=2006-05-23 }}
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{{Anti-inflammatory and antirheumatic products}}
{{Analgesics}}
{{Sodium compounds}}
{{Salicylates}}
{{Prostanoidergics}}

{{DEFAULTSORT:Sodium Salicylate}}
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