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Sodium salicylate

Names
Preferred IUPAC name Sodium 2-hydroxybenzoate
Other names Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
Identifiers
CAS Number	54-21-7
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL447868
ChemSpider	5689
DrugBank	DB01398
ECHA InfoCard	100.000.181
EC Number	200-198-0
KEGG	D00566
PubChem CID	16760658
RTECS number	VO5075000
UNII	WIQ1H85SYP
CompTox Dashboard (EPA)	DTXSID5021708
InChI InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1Key: ABBQHOQBGMUPJH-REWHXWOFAO
SMILES .O=C()c1ccccc1O
Properties
Chemical formula	C7H5NaO3
Molar mass	160.104 g/mol
Appearance	White crystals
Melting point	200 °C (392 °F; 473 K)
Solubility in water	25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C)
Solubility	Soluble in glycerol, 1,4-Dioxane, alcohol
Solubility in methanol	26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)
Pharmacology
ATC code	N02BA04 (WHO)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Harmful
Eye hazards	Irritant
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H314, H331, H400
Precautionary statements	P210, P261, P273, P280, P305+P351+P338, P310
NFPA 704 (fire diamond)	1 1 0
Autoignition temperature	250 °C (482 °F; 523 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose)	930 mg/kg (rats, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is  ?) Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate (wintergreen oil) with an excess of sodium hydroxide.

Properties

This section needs expansion. You can help by adding to it. (July 2024)

Sodium salicylate is of the salicylate family. It is a shiny white powder with an aromatic taste.

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and beta radiation.

References

1. ^ "sodium salicylate". chemister.ru. Archived from the original on 24 May 2014. Retrieved 8 April 2018.
2. Chambers, Michael. "ChemIDplus - 54-21-7 - ABBQHOQBGMUPJH-UHFFFAOYSA-M - Sodium salicylate [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information". chem.sis.nlm.nih.gov. Archived from the original on 9 April 2018. Retrieved 8 April 2018.
3. Sigma-Aldrich Co., Sodium salicylate. Retrieved on 2014-05-26.
4. Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
5. "Sodium salicylate | 54-21-7". ChemicalBook. Archived from the original on 2024-09-02. Retrieved 2024-09-02.
6. "Sodium salicylate | 54-21-7". ChemicalBook. Archived from the original on 2024-09-02. Retrieved 2024-09-02.
7. Klampfer, Lidija; Jörg Cammenga; Hans-Georg Wisniewski; Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386–94. doi:10.1182/blood.V93.7.2386. PMID 10090950.
8. Rae, Colin; Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA. 104 (31): 12790–5. Bibcode:2007PNAS..10412790R. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662.
9. Stark, Lesley A.; et al. (May 2007). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis. 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819.
10. Schwenger, Paul; Edward Y. Skolnik; Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry. 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494.
11. Samson, James. "Vacuum Ultraviolet Spectroscopy" (PDF). Pied Publications. Archived from the original (PDF) on October 16, 2006. Retrieved July 26, 2012.

External links

• Chemicalland21
• vhc
• Some synonyms
• Safety data for sodium salicylate at Oxford University Archived 2006-05-23 at the Wayback Machine
• Sodium salicylate, definitions at National Cancer Institute

• Organic sodium salts
• Salicylates
• 3-Hydroxypropenals