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Etofenamate

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NSAID analgesic medication Pharmaceutical compound
Etofenamate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Topical (cream, gel, spray)
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding98–99%
MetabolitesFlufenamic acid, hydroxyl derivatives
Excretion35% renal, mostly biliary
Identifiers
IUPAC name
  • 2-(2-hydroxyethoxy)ethyl 2-amino]benzoate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.045.650 Edit this at Wikidata
Chemical and physical data
FormulaC18H18F3NO4
Molar mass369.340 g·mol
3D model (JSmol)
SMILES
  • FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)OCCOCCO
InChI
  • InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2
  • Key:XILVEPYQJIOVNB-UHFFFAOYSA-N
  (verify)

Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. It is available for topical application as a cream, a gel or as a spray.

Etofenamate is acutely toxic if swallowed; it is also very toxic to aquatic life, with long lasting effects.

References

  1. Chlud K (1999). "". Wiener Medizinische Wochenschrift (in German). 149 (19–20): 546–7. PMID 10637963.
  2. "Etofenamate". PubChem.
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key: underline indicates initially developed first-in-class compound of specific group; WHO-Essential Medicines; withdrawn drugs; veterinary use.
Topical products for joint and muscular pain (M02)
Anti-inflammatory
preparations,
non-steroids
Pyrazolidines
Acetic acid
derivatives
Other
Capsaicin derivatives
Other
Prostanoid signaling modulators
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
COX
(PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthaseHQL-79
PGFSTooltip Prostaglandin F synthaseBimatoprost
PGI2STooltip Prostacyclin synthaseTranylcypromine
TXASTooltip Thromboxane A synthase
Others
See also
Receptor/signaling modulators
Leukotriene signaling modulators
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