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Aldose-1-phosphate nucleotidyltransferase

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aldose-1-phosphate nucleotidyltransferase
Identifiers
EC no.2.7.7.37
CAS no.9033-61-8
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In enzymology, an aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37) is an enzyme that catalyzes the chemical reaction

NDP + alpha-D-aldose 1-phosphate {\displaystyle \rightleftharpoons } phosphate + NDP-aldose

Thus, the two substrates of this enzyme are NDP and alpha-D-aldose 1-phosphate, whereas its two products are phosphate and NDP-aldose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase. Other names in common use include sugar-1-phosphate nucleotidyltransferase, NDPaldose phosphorylase, glucose 1-phosphate inosityltransferase, NDP sugar phosphorylase, nucleoside diphosphosugar phosphorylase, sugar phosphate nucleotidyltransferase, nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase, sugar nucleotide phosphorylase, and NDP:aldose-1-phosphate nucleotidyltransferase. This enzyme participates in nucleotide sugars metabolism.

References

  • CABIB E, CARMINATTI H, WOYSKOVSKY NM (1965). "PHOSPHOROLYSIS OF THE PYROPHOSPHATE BOND OF SUGAR NUCLEOTIDES. II PURIFICATION AND PROPERTIES OF THE ENZYME". J. Biol. Chem. 240: 2114–21. PMID 14299635.
Transferases: phosphorus-containing groups (EC 2.7)
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor
2.7.2: COOH acceptor
2.7.3: N acceptor
2.7.4: PO4 acceptor
2.7.6: diphosphotransferase
(P2O7)
2.7.7: nucleotidyltransferase
(PO4-nucleoside)
Polymerase
DNA polymerase
DNA-directed DNA polymerase
I/A
γ
θ
ν
T7
Taq
II/B
α
δ
ε
ζ
Pfu
III/C
IV/X
β
λ
μ
TDT
V/Y
η
ι
κ
RNA-directed DNA polymerase
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RNA polymerase I
II
III
IV
V
ssRNAP
POLRMT
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1
2
PrimPol
RNA-dependent RNA polymerase
Polyadenylation
PAP
PNPase
Phosphorolytic
3' to 5' exoribonuclease
Nucleotidyltransferase
Guanylyltransferase
Other
2.7.8: miscellaneous
Phosphatidyltransferases
Glycosyl-1-phosphotransferase
2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)
2.7.10: protein-tyrosine
2.7.11: protein-serine/threonine
2.7.12: protein-dual-specificity
2.7.13: protein-histidine
Enzymes
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