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BD1060

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Chemical compound Pharmaceutical compound
BD1060
Identifiers
IUPAC name
  • N--1-pyrrolidineethanamine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H20Cl2N2
Molar mass287.23 g·mol
3D model (JSmol)
SMILES
  • C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl
InChI
  • InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2
  • Key:KFLJZQLENAVFAL-UHFFFAOYSA-N

BD1060 or N--1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.

See also

References

  1. ^ Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.
Sigma receptor modulators
σ1
σ2
Unsorted
See also: Receptor/signaling modulators
Category: