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ITGA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N
Identifiers
Aliases	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs	OMIM: 607759; MGI: 96601; HomoloGene: 37304; GeneCards: ITGA2B; OMA:ITGA2B - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 44,372,180 bp End 44,389,649 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 66.29 cM Start 102,344,123 bp End 102,360,948 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood trabecular bone granulocyte pancreatic ductal cell gonad testicle right hemisphere of cerebellum bone marrow cells sperm Top expressed in blood tibiofemoral joint embryo yolk sac spleen lip body of femur right kidney gastrula granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding fibrinogen binding extracellular matrix binding identical protein binding metal ion binding Cellular component focal adhesion integrin complex integral component of plasma membrane platelet alpha granule membrane integral component of membrane membrane external side of plasma membrane extracellular exosome plasma membrane blood microparticle cell surface Biological process extracellular matrix organization cell-matrix adhesion positive regulation of leukocyte migration platelet aggregation platelet degranulation cell adhesion integrin-mediated signaling pathway regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3674 16399 Ensembl ENSG00000005961 ENSMUSG00000034664 UniProt P08514 Q9QUM0 RefSeq (mRNA) NM_000419 NM_010575 RefSeq (protein) NP_000410 NP_034705 Location (UCSC) Chr 17: 44.37 – 44.39 Mb Chr 11: 102.34 – 102.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Interactions

ITGA2B has been shown to interact with AUP1 and CLNS1A.

See also

• Cluster of differentiation
• Glycoprotein IIb/IIIa

References

1. ^ GRCh38: Ensembl release 89: ENSG00000005961 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034664 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1): 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
6. "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
7. Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. 277 (32). United States: 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.
8. Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26). United States: 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.

Further reading

• Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
• Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3". Curr. Opin. Hematol. 4 (5): 317–22. doi:10.1097/00062752-199704050-00004. PMID 9288464.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization". Am. J. Cardiol. 82 (8B): 36P – 42P. doi:10.1016/S0002-9149(98)00662-6. PMID 9809890.
• Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936 (1): 340–54. Bibcode:2001NYASA.936..340B. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. S2CID 25431334.
• Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium". Thromb. Haemost. 86 (1): 34–40. doi:10.1055/s-0037-1616198. PMID 11487023. S2CID 74389210.
• Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
• Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. S2CID 42666713.
• Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMC 1297263. PMID 16322781.
• Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms". J. Thromb. Haemost. 5 (7): 1345–52. doi:10.1111/j.1538-7836.2007.02537.x. PMID 17635696. S2CID 12983526.

External links

• CD41+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P08514 (Human Integrin alpha-IIb) at the PDBe-KB.

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