Misplaced Pages

CRTC3
Identifiers
Aliases	CRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDs	OMIM: 608986; MGI: 1917711; HomoloGene: 11248; GeneCards: CRTC3; OMA:CRTC3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.1 Start 90,529,923 bp End 90,645,345 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D2- D3 Start 80,236,375 bp End 80,338,625 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell saphenous vein parotid gland visceral pleura urethra inferior olivary nucleus parietal pleura dorsal motor nucleus of vagus nerve nipple popliteal artery Top expressed in zygote internal carotid artery external carotid artery sciatic nerve Gonadal ridge secondary oocyte Rostral migratory stream genital tubercle lacrimal gland mesenteric lymph nodes More reference expression data BioGPS n/a
Gene ontology Molecular function cAMP response element binding protein binding protein binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process energy homeostasis macrophage activation positive regulation of CREB transcription factor activity viral process negative regulation of lipid catabolic process regulation of transcription, DNA-templated protein homotetramerization negative regulation of cAMP-mediated signaling transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64784 70461 Ensembl ENSG00000140577 ENSMUSG00000030527 UniProt Q6UUV7 Q91X84 RefSeq (mRNA) NM_001042574 NM_022769 NM_173863 RefSeq (protein) NP_001036039 NP_073606 NP_776288 Location (UCSC) Chr 15: 90.53 – 90.65 Mb Chr 7: 80.24 – 80.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.

This gene has been shown to be linked to weight gain.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000140577 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030527 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
6. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
7. "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
8. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature. 468 (7326): 933–939. Bibcode:2010Natur.468..933S. doi:10.1038/nature09564. PMC 3025711. PMID 21164481.

Further reading

• Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry. 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518.
• Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
• Koga H, Ohshima T, Shimotohno K (December 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry. 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• CRTC3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CRTC3 genome location and CRTC3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 15 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 15
• Gene expression
• Transcription coregulators
• Human chromosome 15 gene stubs