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PNRC1

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Protein-coding gene in the species Homo sapiens
PNRC1
Identifiers
AliasesPNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDsOMIM: 606714; MGI: 1917838; HomoloGene: 4960; GeneCards: PNRC1; OMA:PNRC1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)
Chromosome 6 (human)Genomic location for PNRC1Genomic location for PNRC1
Band6q15Start89,080,751 bp
End89,085,160 bp
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)
Chromosome 4 (mouse)Genomic location for PNRC1Genomic location for PNRC1
Band4|4 A5Start33,245,423 bp
End33,290,163 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • gastric mucosa

  • left uterine tube

  • gastrocnemius muscle

  • left ovary

  • muscle of thigh

  • right ovary

  • tibial arteries

  • epithelium of colon

  • gallbladder
Top expressed in
  • left lung lobe

  • medial ganglionic eminence

  • granulocyte

  • lymph node

  • mesenteric lymph nodes

  • lacrimal gland

  • molar

  • thoracic diaphragm

  • submandibular gland

  • digastric muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10957

108767

Ensembl

ENSG00000146278

ENSMUSG00000040128

UniProt

Q12796
Q49A59

Q3TWH3

RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC)Chr 6: 89.08 – 89.09 MbChr 4: 33.25 – 33.29 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR. The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000146278Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040128Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
  6. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
  7. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
  8. ^ Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading

External links

Transcription coregulators
Coactivators
Corepressors
ATP-dependent remodeling factors


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