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Cathepsin H

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(Redirected from CTSH (gene)) Protein-coding gene in the species Homo sapiens
CTSH
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1BZN

Identifiers
AliasesCTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
External IDsOMIM: 116820; MGI: 107285; HomoloGene: 36159; GeneCards: CTSH; OMA:CTSH - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)
Chromosome 15 (human)Genomic location for CTSHGenomic location for CTSH
Band15q25.1Start78,921,058 bp
End78,949,574 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for CTSHGenomic location for CTSH
Band9 E3.1|9 47.4 cMStart89,936,205 bp
End89,958,142 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • optic nerve

  • kidney tubule

  • lower lobe of lung

  • bronchial epithelial cell

  • visceral pleura

  • renal medulla

  • monocyte

  • lymph node

  • upper lobe of lung

  • human kidney
Top expressed in
  • left lung lobe

  • right lung lobe

  • yolk sac

  • parotid gland

  • right kidney

  • mesenteric lymph nodes

  • proximal tubule

  • granulocyte

  • cervix

  • left lobe of liver
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1512

13036

Ensembl

ENSG00000103811

ENSMUSG00000032359

UniProt

P09668

P49935

RefSeq (mRNA)

NM_004390
NM_148979
NM_001319137

NM_007801
NM_001312649

RefSeq (protein)

NP_001306066
NP_004381

NP_001299578
NP_031827

Location (UCSC)Chr 15: 78.92 – 78.95 MbChr 9: 89.94 – 89.96 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin H is a protein that in humans is encoded by the CTSH gene.

The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000103811Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032359Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol Chem Hoppe-Seyler. 369 (6): 469–75. doi:10.1515/bchm3.1988.369.1.469. PMID 2849458.
  6. ^ "Entrez Gene: CTSH cathepsin H".

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: C01.040
PDB gallery
  • 1nb3: Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases 1nb3: Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases
  • 1nb5: Crystal structure of stefin A in complex with cathepsin H 1nb5: Crystal structure of stefin A in complex with cathepsin H
  • 8pch: CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION 8pch: CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION
Proteases: cysteine proteases (EC 3.4.22)
Caspase
Fruit-derived
Calpain
Cathepsin
Other
Enzymes
Activity
Regulation
Classification
Kinetics
Types
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