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The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans. When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.

References

1. Li FF, Gasser RB, Liu F, Shan JN, Di WD, He L, et al. (April 2020). "Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus". Parasites & Vectors. 13 (1): 164. doi:10.1186/s13071-020-04034-0. PMC 7119156. PMID 32245505.
2. Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.

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