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Daf-9

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Cytochrome P450 daf-9
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-9
Alt. symbolsCYP22A1
Entrez180889
RefSeq (mRNA)NM_001029732.2
RefSeq (Prot)NP_001024903.1
UniProtH2KYS3
Other data
ChromosomeX: 6.2 - 6.2 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans, with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will binding it's nuclear receptor Daf-12 and has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva.

References

  1. Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID 11782415.
  2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153. S2CID 4332206.
Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)
CYP1
CYP2
CYP3 (CYP3A)
CYP4
CYP5-20
CYP21-49
CYP51-69
CYP71-99
CYP101-281
CYP301-499
CYP501-699
CYP701-999
Dauer larva related genes
Dauer Formation Abnormal protein
Downstream Of Daf protein
Daf-12-interacting protein
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