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Cytochrome P450, family 109, also known as CYP109, is a cytochrome P450 monooxygenase family, many members are associated with fatty acid hydroxylation. The first gene identified in this family is the CYP109A1 and CYP109B1 from Bacillus subtilis. CYP109 is one of the only three P450 families shared in bacteria and archaea, the other two are CYP147 and CYP197. Genes in this family are co-present on archaeal plasmids and chromosomes, implying the plasmid-mediated horizontal gene transfer of these genes from bacteria to archaea.

References

1. ^ Ngcobo, PE; Nkosi, BVZ; Chen, W; Nelson, DR; Syed, K (19 February 2023). "Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea". International Journal of Molecular Sciences. 24 (4): 4161. doi:10.3390/ijms24044161. PMC 9962201. PMID 36835573.
2. Khatri, Y; Hannemann, F; Girhard, M; Kappl, R; Même, A; Ringle, M; Janocha, S; Leize-Wagner, E; Urlacher, VB; Bernhardt, R (January 2013). "Novel family members of CYP109 from Sorangium cellulosum So ce56 exhibit characteristic biochemical and biophysical properties". Biotechnology and Applied Biochemistry. 60 (1): 18–29. doi:10.1002/bab.1087. PMID 23586989.
3. Girhard M, Klaus T, Khatri Y, Bernhardt R, Urlacher VB (June 2010). "Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis". Applied Microbiology and Biotechnology. 87 (2): 595–607. doi:10.1007/s00253-010-2472-z. PMID 20186410. S2CID 26265331.

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